Cyclin-dependent kinase 3

Cell division protein kinase 3 is an enzyme that in humans is encoded by the CDK3 gene.^[3][4]

"CDK3" redirects here. For the IATA airport code, see Dorset/Kawagama Lake (South) Water Aerodrome.

CDK3
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1LFN
Identifiers
Aliases	CDK3, cyclin dependent kinase 3
External IDs	OMIM: 123828; HomoloGene: 74387; GeneCards: CDK3; OMA:CDK3 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q25.1 Start 76,000,855 bp[1] End 76,005,999 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon right lobe of liver granulocyte pituitary gland right lobe of thyroid gland right uterine tube anterior pituitary gonad prostate spleen n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein serine/threonine kinase activity ATP binding kinase activity nucleotide binding protein kinase activity transferase activity cyclin-dependent protein serine/threonine kinase activity protein binding cyclin binding Cellular component cyclin-dependent protein kinase holoenzyme complex nucleus cytoplasm Biological process cell division cell population proliferation cell cycle G0 to G1 transition cellular response to DNA damage stimulus phosphorylation protein phosphorylation signal transduction multicellular organism development positive regulation of cell population proliferation response to organic substance regulation of G2/M transition of mitotic cell cycle regulation of gene expression G1/S transition of mitotic cell cycle regulation of cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1018 n/a Ensembl ENSG00000250506 n/a UniProt Q00526 n/a RefSeq (mRNA) NM_001258 n/a RefSeq (protein) NP_001249 n/a Location (UCSC) Chr 17: 76 – 76.01 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Function

CDK3 complements cdc28 mutants of Saccharomyces cerevisiae suggesting that it may be involved in cell cycle control. CDK3 can phosphorylate histone H1 and interacts with an unknown type of cyclin.^[4]

References

1. GRCh38: Ensembl release 89: ENSG00000250506 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Meyerson M, Enders GH, Wu CL, Su LK, Gorka C, Nelson C, Harlow E, Tsai LH (Aug 1992). "A family of human cdc2-related protein kinases". EMBO J. 11 (8): 2909–17. doi:10.1002/j.1460-2075.1992.tb05360.x. PMC 556772. PMID 1639063.
4. "Entrez Gene: CDK3 cyclin-dependent kinase 3".

Further reading

• Bullrich F, MacLachlan TK, Sang N, et al. (1995). "Chromosomal mapping of members of the cdc2 family of protein kinases, cdk3, cdk6, PISSLRE, and PITALRE, and a cdk inhibitor, p27Kip1, to regions involved in human cancer". Cancer Res. 55 (6): 1199–205. PMID 7882308.
• Gyuris J, Golemis E, Chertkov H, Brent R (1993). "Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2". Cell. 75 (4): 791–803. doi:10.1016/0092-8674(93)90498-F. PMID 8242750.
• Sasaguri T, Ishida A, Kosaka C, et al. (1996). "Phorbol ester inhibits the phosphorylation of the retinoblastoma protein without suppressing cyclin D-associated kinase in vascular smooth muscle cells". J. Biol. Chem. 271 (14): 8345–51. doi:10.1074/jbc.271.14.8345. PMID 8626531.
• Meikrantz W, Schlegel R (1996). "Suppression of apoptosis by dominant negative mutants of cyclin-dependent protein kinases". J. Biol. Chem. 271 (17): 10205–9. doi:10.1074/jbc.271.17.10205. PMID 8626584.
• Hofmann F, Livingston DM (1996). "Differential effects of cdk2 and cdk3 on the control of pRb and E2F function during G1 exit". Genes Dev. 10 (7): 851–61. doi:10.1101/gad.10.7.851. PMID 8846921.
• Lamphere L, Fiore F, Xu X, et al. (1997). "Interaction between Cdc37 and Cdk4 in human cells". Oncogene. 14 (16): 1999–2004. doi:10.1038/sj.onc.1201036. PMID 9150368. S2CID 25236893.
• Braun K, Hölzl G, Soucek T, et al. (1998). "Investigation of the cell cycle regulation of cdk3-associated kinase activity and the role of cdk3 in proliferation and transformation". Oncogene. 17 (17): 2259–69. doi:10.1038/sj.onc.1202145. PMID 9811456. S2CID 12470182.
• Yamochi T, Semba K, Tsuji K, et al. (2002). "ik3-1/Cables is a substrate for cyclin-dependent kinase 3 (cdk 3)". Eur. J. Biochem. 268 (23): 6076–82. doi:10.1046/j.0014-2956.2001.02555.x. PMID 11733001.
• Sato H, Nishimoto I, Matsuoka M (2002). "ik3-2, a relative to ik3-1/cables, is associated with cdk3, cdk5, and c-abl". Biochim. Biophys. Acta. 1574 (2): 157–63. doi:10.1016/S0167-4781(01)00367-0. PMID 11955625.
• Schang LM, Bantly A, Schaffer PA (2002). "Explant-induced reactivation of herpes simplex virus occurs in neurons expressing nuclear cdk2 and cdk4". J. Virol. 76 (15): 7724–35. doi:10.1128/JVI.76.15.7724-7735.2002. PMC 136347. PMID 12097586.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Ren S, Rollins BJ (2004). "Cyclin C/cdk3 promotes Rb-dependent G0 exit". Cell. 117 (2): 239–51. doi:10.1016/S0092-8674(04)00300-9. PMID 15084261. S2CID 890866.
• Zhang Y, Wolf-Yadlin A, Ross PL, et al. (2005). "Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules". Mol. Cell. Proteomics. 4 (9): 1240–50. doi:10.1074/mcp.M500089-MCP200. PMID 15951569.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Wissing J, Jänsch L, Nimtz M, et al. (2007). "Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry" (PDF). Mol. Cell. Proteomics. 6 (3): 537–47. doi:10.1074/mcp.T600062-MCP200. PMID 17192257. S2CID 40974821.

External links

• CDK3+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• CDK3 human gene location in the UCSC Genome Browser.
• CDK3 human gene details in the UCSC Genome Browser.