Prasterone enanthate
Chemical compound / From Wikipedia, the free encyclopedia
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Prasterone enanthate, also known as dehydroepiandrosterone enanthate (DHEA-E) and sold in combination with estradiol valerate under the brand name Gynodian Depot among others, is a weak androgen, estrogen, and neurosteroid medication which is used as a component of menopausal hormone therapy to treat menopausal symptoms in women.[3][1][4][5][6][7][8][9][10] It is available only as an injectable preparation in combination with estradiol valerate.[3][11][12][13] The medication is given by injection into muscle typically once every 4 weeks.[3][1][4]
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Trade names | With estradiol valerate: Gynodian Depot, others |
Other names | DHEA enanthate; Prasterone heptanoate; DHEA heptanoate; DHEA-E; EDHEA; SH-90300-D; SH-70833-D (with EVTooltip estradiol valerate); Androst-5-en-3β-ol-17-one 3β-heptanoate |
Routes of administration | Intramuscular injection |
Drug class | Androgen; Anabolic steroid; Androgen ester; Estrogen; Neurosteroid |
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Pharmacokinetic data | |
Bioavailability | IM: 100%[1] |
Metabolites | • Prasterone (DHEA)[1] • Others[1] |
Elimination half-life | IM: 9 days[1] IV: 44 minutes[1] |
Duration of action | 18 days[2] |
Excretion | Urine, feces[1] |
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ECHA InfoCard | 100.041.777 |
Chemical and physical data | |
Formula | C26H40O3 |
Molar mass | 400.603 g·mol−1 |
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Prasterone enanthate is a synthetic androgen, estrogen, and neurosteroid.[3][1][4] It is a steroid ester and a long-lasting prodrug of prasterone (dehydroepiandrosterone; DHEA) in the body.[3][1][4] Prasterone is a naturally occurring prohormone of androgens and estrogens and hence is an agonist of the androgen and estrogen receptors, the respective biological targets of androgens like testosterone and estrogens like estradiol.[14][15] Prasterone also has a variety of activities of its own, including neurosteroid and other activities.[15] An injection of prasterone enanthate has a duration of action in terms of elevated prasterone levels of about 18 days.[3][1][4]
The combination of estradiol valerate and prasterone enanthate was developed as early as 1966 and was introduced for medical use in 1975.[16][17] The formulation is marketed widely throughout Europe, and is also available in several Latin American countries and in Egypt.[11][12][18][13][19] It is not available in any predominantly English-speaking countries.[11][19]