Dextromethorphan/quinidine
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Dextromethorphan/quinidine, sold under the brand name Nuedexta, is a fixed-dose combination medication for the treatment of pseudobulbar affect (PBA).[1][2] It contains dextromethorphan (DXM) and the class I antiarrhythmic agent quinidine.[1]
Not to be confused with Deudextromethorphan/quinidine.
Quick Facts Combination of, Quinidine ...
Combination of | |
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Dextromethorphan | Sigma-1 receptor agonist, NMDA receptor antagonist, serotonin–norepinephrine reuptake inhibitor |
Quinidine | Antiarrhythmic agent, CYP2D6 inhibitor |
Clinical data | |
Trade names | Nuedexta |
Other names | AVP-923; DXM/quinidine |
AHFS/Drugs.com | Monograph |
MedlinePlus | a611048 |
License data | |
Routes of administration | By mouth |
ATC code |
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Pharmacokinetic data | |
Bioavailability | dextromethorphan 11%, quinidine 70-80%. Food has no effect on absorption. |
Metabolism | Liver, extensive. Dextromethorphan is catalyzed by CYP2D6. Quinidine is metabolized by CYP3A4 and competitively inhibits the metabolism of dextromethorphan to increase and prolong plasma concentrations of dextromethorphan |
Elimination half-life | dextromethorphan 13h, quinidine 7h |
Excretion | quinidine 5-20% |
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CAS Number | |
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Dextromethorphan/quinidine was approved for medical use in the United States in October 2010, and is marketed by Avanir Pharmaceuticals.[3]