Exemestane
Breast cancer medication / From Wikipedia, the free encyclopedia
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Exemestane, sold under the brand name Aromasin among others, is a medication used to treat breast cancer. It is a member of the class of antiestrogens known as aromatase inhibitors. Some breast cancers require estrogen to grow. Those cancers have estrogen receptors (ERs), and are called ER-positive. They may also be called estrogen-responsive, hormonally-responsive, or hormone-receptor-positive. Aromatase is an enzyme that synthesizes estrogen. Aromatase inhibitors block the synthesis of estrogen. This lowers the estrogen level, and slows the growth of cancers.
Quick Facts Clinical data, Pronunciation ...
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Pronunciation | /ˌɛksəˈmɛˌsteɪn/ EK-sə-ME-stayn |
Trade names | Aromasin |
Other names | FCE-24304 |
AHFS/Drugs.com | Monograph |
MedlinePlus | a607006 |
Routes of administration | By mouth |
Drug class | Aromatase inhibitor; Antiestrogen |
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Bioavailability | ~60%[citation needed] |
Protein binding | 90% |
Metabolism | Liver (CYP3A4, aldo-keto reductase) |
Elimination half-life | 24 hours |
Duration of action | 4–5 days[citation needed] |
Excretion | Urine and feces ~ 1:1 (mainly metabolites) |
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ECHA InfoCard | 100.171.149 |
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Formula | C20H24O2 |
Molar mass | 296.410 g·mol−1 |
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