Fenfluramine/phentermine
Drug combination prescribed for weight loss; later withdrawn from market / From Wikipedia, the free encyclopedia
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The drug combination fenfluramine/phentermine, usually called fen-phen, was an anti-obesity treatment in the early 1990s that utilized two anorectics. Fenfluramine was marketed by American Home Products (later known as Wyeth) as Pondimin, but was shown to cause potentially fatal pulmonary hypertension and heart valve problems, which eventually led to its withdrawal in 1997 and legal damages of over $13 billion.[1] Phentermine was not shown to have harmful effects.[1]
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Fenfluramine | Serotoninergic |
Phentermine | Adrenergic, dopaminergic, serotoninergic |
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Routes of administration | Oral |
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Fenfluramine acts as a serotonin releasing agent,[2] phentermine as primarily a norepinephrine releasing agent. Phentermine also induces the release of serotonin and dopamine, although to a far lesser extent than it induces the release of norepinephrine.[3]