Haemophilia A
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Haemophilia A (or hemophilia A) is a blood clotting disorder caused by a genetic deficiency in clotting factor VIII, thereby resulting in significant susceptibility to bleeding, both internally and externally. This condition occurs almost exclusively in males born to carrier mothers due to X-linked recessive inheritance. Nevertheless, rare isolated cases do emerge from de novo (spontaneous) mutations.[2][3][4]
Haemophilia A | |
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Other names | Hemophilia A |
Protein structure of coagulation factor VIII, of which its deficiency is the cause of haemophilia A. | |
Specialty | Haematology |
Symptoms | Prolonged bleeding from common injuries[1] |
Causes | Factor VIII deficiency[2] |
Diagnostic method | Bleeding time,[2] coagulation screen, genetic testing |
Prevention | Hepatitis B vaccine should be considered[2] |
Treatment | Factor VIII, factor VIII inhibitors, emicizumab |
The medical management of individuals with hemophilia A frequently entails the administration of factor VIII medication through slow intravenous injection. This intervention aims to address and preempt additional bleeding episodes in affected individuals.