Leber congenital amaurosis
Rare inherited eye disease / From Wikipedia, the free encyclopedia
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Leber congenital amaurosis (LCA) is a rare inherited eye disease that appears at birth or in the first few months of life.[2]
Quick Facts Other names, Specialty ...
Leber congenital amaurosis | |
---|---|
Other names | Leber's congenital amaurosis |
Specialty | Ophthalmology |
Symptoms | Visual impairment, sensitivity to light[1] |
Types | > 12 types[1] |
Causes | Genetic (autosomal recessive)[1] |
Frequency | 1 in 40,000 newborns[1] |
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It affects about 1 in 40,000 newborns.[1] LCA was first described by Theodor Leber in the 19th century.[3][4] It should not be confused with Leber's hereditary optic neuropathy, which is a different disease also described by Theodor Leber.
One form of LCA was successfully treated with gene therapy in 2008.[5][6][7][8]