Sequestosome 1
Protein-coding gene in the species Homo sapiens / From Wikipedia, the free encyclopedia
Sequestosome-1 is a protein that in humans is encoded by the SQSTM1 gene.[5][6][7] Also known as the ubiquitin-binding protein p62,[8] it is an autophagosome cargo protein that targets other proteins that bind to it for selective autophagy. By interacting with GATA4 and targeting it for degradation, it can inhibit GATA-4 associated senescence and senescence-associated secretory phenotype.[9]
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Mutations in SQSTM1 are a common cause of Paget's disease of bone.[10]