User:Kpangakis/Non-synaptic plasticity draft
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Nonsynaptic plasticity is a form of neuroplasticity that involves modification of ion channel function in the axon, dendrites, and cell body that results in specific changes in the integration of EPSPs and IPSPs, thus modifying the intrinsic excitability of the neuron. It interacts with Synaptic plasticity, however it is considered separate from synaptic plasticity itself. This process is visible in neurons that are actively involved in learning. Nonsynaptic plasticity affects synaptic integration, subthreshold propagation, spike generation, and other fundamental mechanisms of neurons at the neuronal level. These individual neuronal alterations can result in changes in higher brain function, especially concerning learning and memory. However, as an emerging field in neuroscience, much of the knowledge about nonsynaptic plasticity is uncertain and still requires further investigation to better define its role in brain function and behavior.