Pantoprazole
Stomach acid suppressing medication / From Wikipedia, the free encyclopedia
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Pantoprazole, sold under the brand name Protonix, among others, is a proton pump inhibitor used for the treatment of stomach ulcers, short-term treatment of erosive esophagitis due to gastroesophageal reflux disease (GERD), maintenance of healing of erosive esophagitis, and pathological hypersecretory conditions including Zollinger–Ellison syndrome.[5][6] It may also be used along with other medications to eliminate Helicobacter pylori.[7] Effectiveness is similar to other proton pump inhibitors (PPIs).[8] It is available by mouth and by injection into a vein.[5]
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Trade names | Protonix, others[1] |
AHFS/Drugs.com | Monograph |
MedlinePlus | a601246 |
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Routes of administration | By mouth and intravenous |
Drug class | proton pump inhibitor |
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Bioavailability | 77% |
Protein binding | 98% |
Metabolism | Liver (CYP2C19, CYP3A4) |
Elimination half-life | 1-2 hours |
Excretion | Urine, feces |
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ECHA InfoCard | 100.111.005 |
Chemical and physical data | |
Formula | C16H15F2N3O4S |
Molar mass | 383.37 g·mol−1 |
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Chirality | Racemic |
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Common side effects include headaches, diarrhea, vomiting, abdominal pain, and joint pain.[5][6] More serious side effects may include severe allergic reactions, a type of chronic inflammation known as atrophic gastritis, Clostridium difficile colitis, low magnesium, and vitamin B12 deficiency.[5] Use in pregnancy appears to be safe.[5] Pantoprazole is a proton pump inhibitor that decreases gastric acid secretion.[5] It works by inactivating (H+/K+)-ATPase function in the stomach.[9][5]
Study of pantoprazole began in 1985, and it came into medical use in Germany in 1994.[10] It is available as a generic medication.[5][11] In 2021, it was the nineteenth most commonly prescribed medication in the United States, with more than 27 million prescriptions.[12][13]