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锁核酸（Locked nucleic acid，LNA）是一种经过修饰的RNA，LNA中一部分核糖上的2'与4'碳连结在一起。一般可见于A-DNA或RNA。
这类核酸可以增加引子或探针（probe）的融解温度（Tm值），加强这些实验用物质的稳定性，可应用在即时聚合酶连锁反应（real-time PCR）等技术中。
- Kaur, H.; Arora, A.; Wengel, J.; Maiti, S. Thermodynamic, Counterion, and Hydration Effects for the Incorporation of Locked Nucleic Acid Nucleotides into DNA Duplexes. Biochemistry. 2006, 45 (23): 7347–55. doi:10.1021/bi060307w.
- A predictor for the physical properties of LNA modified oligonucleotides
- LNA (locked nucleic acid): high-affinity targeting of complementary RNA and DNA （页面存档备份，存于互联网档案馆）
- LNA: a versatile tool for therapeutics and genomics （页面存档备份，存于互联网档案馆）
- Alternative Nucleic Acid Analogues for Programmable Assembly: Hybridization of LNA to PNA （页面存档备份，存于互联网档案馆）
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