(−)-β-Pinene synthase (EC 4.2.3.120, β-geraniolene synthase, (−)-(1S,5S)-pinene synthase, geranyldiphosphate diphosphate lyase (pinene forming)) is an enzyme with systematic name geranyl-diphosphate diphosphate-lyase [cyclizing, (−)-β-pinene-forming].[1][2][3][4][5][6][7][8][9][10][11][12] This enzyme catalyses the following chemical reaction
- geranyl diphosphate (−)-β-pinene + diphosphate
Quick Facts (−)-β-pinene synthase, Identifiers ...
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Cyclase II of Salvia officinalis (sage) produces about equal parts (−)-α-pinene, (−)-β-pinene and (−)-camphene.
Croteau RB, Wheeler CJ, Cane DE, Ebert R, Ha HJ (August 1987). "Isotopically sensitive branching in the formation of cyclic monoterpenes: proof that (–)-α-pinene and (–)-β-pinene are synthesized by the same monoterpene cyclase via deprotonation of a common intermediate". Biochemistry. 26 (17): 5383–9. doi:10.1021/bi00391a025. PMID 3314988.
Pyun HJ, Wagschal KC, Jung DI, Coates RM, Croteau R (February 1994). "Stereochemistry of the proton elimination in the formation of (+)- and (–)-α-pinene by monoterpene cyclases from sage (Salvia officinalis)". Archives of Biochemistry and Biophysics. 308 (2): 488–96. doi:10.1006/abbi.1994.1069. PMID 8109979.
Gijzen M, Lewinsohn E, Croteau R (September 1991). "Characterization of the constitutive and wound-inducible monoterpene cyclases of grand fir (Abies grandis)". Archives of Biochemistry and Biophysics. 289 (2): 267–73. doi:10.1016/0003-9861(91)90471-T. PMID 1898071.
Lewinsohn E, Gijzen M, Croteau R (February 1992). "Wound-inducible pinene cyclase from grand fir: purification, characterization, and renaturation after SDS-PAGE". Archives of Biochemistry and Biophysics. 293 (1): 167–73. doi:10.1016/0003-9861(92)90380-f. PMID 1731633.
Hyatt DC, Croteau R (July 2005). "Mutational analysis of a monoterpene synthase reaction: altered catalysis through directed mutagenesis of (-)-pinene synthase from Abies grandis". Archives of Biochemistry and Biophysics. 439 (2): 222–33. doi:10.1016/j.abb.2005.05.017. PMID 15978541.
Savage TJ, Ichii H, Hume SD, Little DB, Croteau R (July 1995). "Monoterpene synthases from gymnosperms and angiosperms: stereospecificity and inactivation by cysteinyl- and arginyl-directed modifying reagents". Archives of Biochemistry and Biophysics. 320 (2): 257–65. doi:10.1016/0003-9861(95)90008-x. PMID 7625832.
Phillips MA, Savage TJ, Croteau R (December 1999). "Monoterpene synthases of loblolly pine (Pinus taeda) produce pinene isomers and enantiomers". Archives of Biochemistry and Biophysics. 372 (1): 197–204. doi:10.1006/abbi.1999.1467. PMID 10562434.