In enzymology, a 17α-hydroxyprogesterone aldolase (EC 4.1.2.30) is an enzyme that catalyzes the chemical reaction
- 17α-hydroxyprogesterone androst-4-en-3,17-dione + acetaldehyde
 | This article includes a list of references, related reading, or external links, but its sources remain unclear because it lacks inline citations. (June 2022) |
| 17α-Hydroxyprogesterone aldolase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 4.1.2.30 | ||||||||
| CAS no. | 62213-24-5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Hence, this enzyme has one substrate, 17α-hydroxyprogesterone, and two products, androst-4-en-3,17-dione and acetaldehyde.
This enzyme belongs to the family of lyases, specifically the aldehyde-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 17α-hydroxyprogesterone acetaldehyde-lyase (4-androstene-3,17-dione-forming). Other names in common use include C-17/C-20-lyase, and 17α-hydroxyprogesterone acetaldehyde-lyase. This enzyme participates in androgen and estrogen metabolism.
References
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