3beta-hydroxy-5alpha-steroid dehydrogenase
Enzyme / From Wikipedia, the free encyclopedia
In enzymology, a 3β-hydroxy-5α-steroid dehydrogenase (EC 1.1.1.278) is an enzyme that catalyzes the chemical reaction
- 3β-hydroxy-5α-pregnane-20-one + NADP+ 5α-pregnan-3,20-dione + NADPH + H+
Quick Facts 3β-hydroxy-5α-steroid dehydrogenase, Identifiers ...
3β-hydroxy-5α-steroid dehydrogenase | |||||||||
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Identifiers | |||||||||
EC no. | 1.1.1.278 | ||||||||
CAS no. | 9015-81-0 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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This article includes a list of general references, but it lacks sufficient corresponding inline citations. (October 2021) |
Thus, the two substrates of this enzyme are 3β-hydroxy-5α-pregnane-20-one (allopregnanolone) and NADP+, whereas its 3 products are 5α-pregnan-3,20-dione, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 3β-hydroxy-5α-steroid:NADP+ 3-oxidoreductase.