4-hydroxy-4-methyl-2-oxoglutarate aldolase
Class of enzymes / From Wikipedia, the free encyclopedia
The enzyme 4-hydroxy-4-methyl-2-oxoglutarate aldolase (EC 4.1.3.17) catalyzes the chemical reaction
- 4-hydroxy-4-methyl-2-oxoglutarate 2 pyruvate
Quick Facts Identifiers, EC no. ...
4-hydroxy-4-methyl-2-oxoglutarate aldolase | |||||||||
---|---|---|---|---|---|---|---|---|---|
Identifiers | |||||||||
EC no. | 4.1.3.17 | ||||||||
CAS no. | 37290-65-6 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
|
Close
This enzyme belongs to the family of lyases, specifically the oxo-acid-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 4-hydroxy-4-methyl-2-oxoglutarate pyruvate-lyase (pyruvate-forming). Other names in common use include pyruvate aldolase, gamma-methyl-gamma-hydroxy-alpha-ketoglutaric aldolase, 4-hydroxy-4-methyl-2-ketoglutarate aldolase, and 4-hydroxy-4-methyl-2-oxoglutarate pyruvate-lyase. This enzyme participates in benzoate degradation via hydroxylation and c5-branched dibasic acid metabolism.