6-carboxyhexanoate—CoA ligase
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In enzymology, a 6-carboxyhexanoate—CoA ligase (EC 6.2.1.14) is an enzyme that catalyzes the chemical reaction
- ATP + 6-carboxyhexanoate + CoA AMP + diphosphate + 6-carboxyhexanoyl-CoA
Quick Facts Identifiers, EC no. ...
6-Carboxyhexanoate—CoA ligase | |||||||||
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Identifiers | |||||||||
EC no. | 6.2.1.14 | ||||||||
CAS no. | 55467-50-0 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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The 3 substrates of this enzyme are ATP, 6-carboxyhexanoate, and CoA, whereas its 3 products are AMP, diphosphate, and 6-carboxyhexanoyl-CoA.
This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is 6-carboxyhexanoate:CoA ligase (AMP-forming). Other names in common use include 6-carboxyhexanoyl-CoA synthetase, and pimelyl-CoA synthetase. This enzyme participates in biotin metabolism.