ADP-ribosylhydrolase 1
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(ADP-ribosyl)hydrolase 1, also termed [Protein ADP-ribosylarginine] hydrolase and protein-Nω-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase (EC 3.2.2.19), is an enzyme that in humans is encoded by the ADPRH gene.[1][2][3][4][5] This enzyme is a specific mono(ADP-ribosyl)hydrolase that catalyses the removal of an ADP-ribosyl modification from target arginine residues of protein substrates.[4][6] The chemical reactions can formally be described as follows:
- Nω-(ADP-D-ribosyl)-L-arginyl-[protein] + H2O ADP-D-ribose + L-arginyl-[protein]
- In addition, the enzyme can reverse the ADP-ribosylation of free arginine:[6][7][8]
- Nω-(ADP-D-ribosyl)-L-arginine + H2O ADP-D-ribose + L-arginine
Quick Facts Identifiers, EC no. ...
ADP-ribosylhydrolase 1 | |||||||||
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Identifiers | |||||||||
EC no. | 3.2.2.19 | ||||||||
CAS no. | 98668-52-1 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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