required to recruit ATM to the sites of DNA double strand breaks. Mre11 and Nbs1 are also targets for phosphorylation by the ATM kinase. Thus, the similarity
strand breaks. ATM is specifically for the damage response to double strand breaks. The MRN complex (composed of Mre11, Rad50, and Nbs1) form immediately
slowed mitosis. MDC1 has been shown to interact with: APC/C, ATM, CHEK2, γH2AX, H2AFX, MRE11A, NBS1, RAD51, RNF8, TOPOα, p53, and MDM2 MDC1 also binds to mRNA