ATPase, Na+/K+ transporting, alpha 1
Protein-coding gene in the species Homo sapiens / From Wikipedia, the free encyclopedia
Sodium/potassium-transporting ATPase subunit alpha-1 is an enzyme that in humans is encoded by the ATP1A1 gene.[5]
Gastric H+/K+-ATPase, N terminal domain | |||||||||
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Identifiers | |||||||||
Symbol | H-K_ATPase_N | ||||||||
Pfam | PF09040 | ||||||||
InterPro | IPR015127 | ||||||||
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The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+-ATPases. Na+/K+-ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+-ATPase is encoded by multiple genes. This gene encodes an alpha 1 subunit. Alternatively spliced transcript variants encoding different isoforms have been identified.[5]
In melanocytic cells ATP1A1 gene expression may be regulated by MITF.[6]