Activin type 2 receptors
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The activin type 2 receptors belong to a larger TGF-beta receptor family and modulate signals for transforming growth factor beta ligands. These receptors are involved in a host of physiological processes including, growth, cell differentiation, homeostasis, osteogenesis, apoptosis and many other functions. There are two activin type two receptors: ACVR2A and ACVR2B.
activin A receptor, type IIA | |||||||
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Identifiers | |||||||
Symbol | ACVR2A | ||||||
Alt. symbols | ACVR2 | ||||||
NCBI gene | 92 | ||||||
HGNC | 173 | ||||||
OMIM | 102581 | ||||||
RefSeq | NM_001616 | ||||||
UniProt | P27037 | ||||||
Other data | |||||||
Locus | Chr. 2 q22.2-23.3 | ||||||
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activin A receptor, type IIB | |||||||
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Identifiers | |||||||
Symbol | ACVR2B | ||||||
NCBI gene | 93 | ||||||
HGNC | 174 | ||||||
OMIM | 602730 | ||||||
RefSeq | NM_001106 | ||||||
UniProt | Q13705 | ||||||
Other data | |||||||
Locus | Chr. 3 p22 | ||||||
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Despite the large amount of processes that these ligands regulate, they all operate through essentially the same pathway: A ligand binds to a type 2 receptor, which recruits and trans-phosphorylates a type I receptor. The type I receptor recruits a receptor regulated SMAD (R-SMAD) which it phosphorylates. The RSMAD then translocates to the nucleus where it functions as a transcription factor.