Aldosterone synthase
Protein-coding gene in the species Homo sapiens / From Wikipedia, the free encyclopedia
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Aldosterone synthase, also called steroid 18-hydroxylase, corticosterone 18-monooxygenase or P450C18, is a steroid hydroxylase cytochrome P450 enzyme involved in the biosynthesis of the mineralocorticoid aldosterone and other steroids. The enzyme catalyzes sequential hydroxylations of the steroid angular methyl group at C18 after initial 11β-hydroxylation (the enzyme has steroid 18-hydroxylase activity as well as steroid 11 beta-hydroxylase activity). It is encoded by the CYP11B2 gene in humans.
Aldosterone synthase is a protein which is only expressed in the zona glomerulosa[5] of the adrenal cortex and is primarily regulated by the renin–angiotensin system.[6] It is the sole enzyme capable of synthesizing aldosterone in humans and plays an important role in electrolyte balance and blood pressure.[7]