Alfaxalone
Chemical compound / From Wikipedia, the free encyclopedia
Dear Wikiwand AI, let's keep it short by simply answering these key questions:
Can you list the top facts and stats about Alphaxolone?
Summarize this article for a 10 year old
Alfaxalone, also known as alphaxalone or alphaxolone and sold under the brand name Alfaxan, is a neuroactive steroid and general anesthetic which is used currently in veterinary practice as an induction agent for anesthesia and as an injectable anesthetic.[1][2][3] Though it is more expensive than other induction agents,[4] it often preferred due to the lack of depressive effects on the cardiovascular system. The most common side effect seen in current veterinary practice is respiratory depression when Alfaxan is administered concurrently with other sedative and anesthetic drugs; when premedications aren't given, veterinary patients also become agitated and hypersensitive when waking up.
Clinical data | |
---|---|
Trade names | Alfaxan |
Other names | Alphaxalone; Alphaxolone; Alfaxolone; 3α-Hydroxy-5α-pregnane-11,20-dione; PHAX-001; Phaxan, Alphaxalone (BAN UK) |
AHFS/Drugs.com | International Drug Names |
License data | |
Drug class | |
ATCvet code | |
Legal status | |
Legal status |
|
Pharmacokinetic data | |
Protein binding | 30–50% |
Metabolism | Hepatic |
Metabolites |
|
Elimination half-life |
|
Excretion | Mostly renal |
Identifiers | |
| |
CAS Number | |
PubChem CID | |
IUPHAR/BPS | |
DrugBank |
|
ChemSpider |
|
UNII | |
KEGG |
|
ChEMBL | |
CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.164.405 |
Chemical and physical data | |
Formula | C21H32O3 |
Molar mass | 332.484 g·mol−1 |
3D model (JSmol) | |
| |
| |
(verify) |
Alfaxalone works as a positive allosteric modulator on GABAA receptors and, at high concentrations, as a direct agonist of the GABAA receptor. It is cleared quickly by the liver, giving it a relatively short terminal half-life and preventing it from accumulating in the body, lowering the chance of overdose.