Amyloid beta
Group of peptides / From Wikipedia, the free encyclopedia
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Amyloid beta (Aβ or Abeta) denotes peptides of 36–43 amino acids that are the main component of the amyloid plaques found in the brains of people with Alzheimer's disease.[2] The peptides derive from the amyloid-beta precursor protein (APP), which is cleaved by beta secretase and gamma secretase to yield Aβ in a cholesterol-dependent process and substrate presentation.[3] Aβ molecules can aggregate to form flexible soluble oligomers which may exist in several forms. It is now believed that certain misfolded oligomers (known as "seeds") can induce other Aβ molecules to also take the misfolded oligomeric form, leading to a chain reaction akin to a prion infection. The oligomers are toxic to nerve cells.[4] The other protein implicated in Alzheimer's disease, tau protein, also forms such prion-like misfolded oligomers, and there is some evidence that misfolded Aβ can induce tau to misfold.[5][6]
Amyloid beta peptide (beta-APP) | |||||||||
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Identifiers | |||||||||
Symbol | APP | ||||||||
Pfam | PF03494 | ||||||||
InterPro | IPR013803 | ||||||||
SCOP2 | 2lfm / SCOPe / SUPFAM | ||||||||
TCDB | 1.C.50 | ||||||||
OPM superfamily | 304 | ||||||||
OPM protein | 2y3k | ||||||||
Membranome | 45 | ||||||||
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amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease) | |||||||
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Identifiers | |||||||
Symbol | APP | ||||||
Alt. symbols | AD1 | ||||||
NCBI gene | 351 | ||||||
HGNC | 620 | ||||||
OMIM | 104760 | ||||||
RefSeq | NM_000484 | ||||||
UniProt | P05067 | ||||||
Other data | |||||||
Locus | Chr. 21 q21.2 | ||||||
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A study has suggested that APP and its amyloid potential is of ancient origins, dating as far back as early deuterostomes.[7]