Aralkylamine dehydrogenase (azurin)
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Aralkylamine dehydrogenase (azurin) (EC 1.4.9.2, aromatic amine dehydrogenase, arylamine dehydrogenase, tyramine dehydrogenase) is an enzyme with the systematic name aralkylamine:azurin oxidoreductase (deaminating).[1][2][3][4][5] This enzyme catalyses the following chemical reaction:
- ArCH2NH2 + H2O + 2 azurin ArCHO + NH3 + 2 reduced azurin
Aralkylamine dehydrogenase (azurin) | |||||||||
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Identifiers | |||||||||
EC no. | 1.4.9.2 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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The three substrates of this enzyme are RCH2NH2 (i.e., an aromatic amine), water, and the acceptor azurin, and its three products are RCHO, ammonia, and a reduced acceptor. Azurin can be replaced with the artificial acceptor phenazine methosulfate in in vitro studies.[1]
This quinoprotein enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH2 group of donors with other acceptors. This enzyme participates in tyrosine metabolism and phenylalanine metabolism. It is notable for its chemical mechanism, which is dominated by proton tunneling.[6]