Arsthinol
Chemical compound / From Wikipedia, the free encyclopedia
Arsthinol (INN) is an antiprotozoal agent. It was synthesized for the first time in 1949 by Ernst A.H. Friedheim by complexation of acetarsol with 2,3-dimercaptopropanol (British anti-Lewisite)[2] and has been demonstrated to be effective against amoebiasis and yaws. It was marketed few years later by Endo Products (Balarsen, Tablets, 0.1 g).[3] Among trivalent organoarsenicals, arsthinol was considered as very well tolerated.[4] Recently, it was studied for its anticancer activity.[5][6]
Quick Facts Names, Identifiers ...
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Preferred IUPAC name
N-{2-Hydroxy-5-[4-(hydroxymethyl)-1,3,2-dithiarsolan-2-yl]phenyl}acetamide | |
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ECHA InfoCard | 100.003.965 |
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Properties | |
C11H14AsNO3S2 | |
Molar mass | 347.28 g·mol−1 |
Pharmacology | |
P01AR01 (WHO) QP51AD01 (WHO) | |
Oral | |
Pharmacokinetics: | |
89 % Hepatic[1] | |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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