Aspirin/paracetamol/caffeine is a combination drug for the treatment of pain, especially tension headache and migraine. It contains aspirin, a non-steroidal
under a number of different brand names. Common brand names include Tylenol, Excedrin, Calpol, and Panadol. Tylenol is a brand of drugs advertised for reducing
acetaminophen/paracetamol in 1956 and ibuprofen in 1962. In the 1960s and 1970s, John Vane and others discovered the basic mechanism of aspirin's effects,: 226–231