Atrolysin A
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Atrolysin A (EC 3.4.24.1) is an enzyme that is one of six hemorrhagic toxins found in the venom of western diamondback rattlesnake. This endopeptidase has a length of 419 amino acid residues.[1][2][3][4] The metalloproteinase disintegrin-like domain and the cysteine-rich domain of the enzyme are responsible for the enzyme's hemorrhagic effects on organisms via inhibition of platelet aggregation.[5][6][7]
Quick Facts Identifiers, EC no. ...
Atrolysin A | |||||||||
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Identifiers | |||||||||
EC no. | 3.4.24.1 | ||||||||
CAS no. | 37288-82-7 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Quick Facts Zinc metalloproteinase-disintegrin-like atrolysin-A, Identifiers ...
Zinc metalloproteinase-disintegrin-like atrolysin-A | |||||||
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Identifiers | |||||||
Organism | Crotalus atrox | ||||||
Symbol | N/A | ||||||
CAS number | 37288-82-7 | ||||||
UniProt | Q92043 | ||||||
Other data | |||||||
EC number | 3.4.24.1 | ||||||
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This enzyme catalyzes the following chemical reactions:
- cleavage of peptide bonds between amino acid residues Asn3-Gln4, His5-Leu6, His10-Leu11, Ala14-Leu15 and Tyr16-Leu17 in the insulin B chain
- removal of the C-terminal Leu from small peptides