Atropisomer
Stereoisomerism due to hindered rotation / From Wikipedia, the free encyclopedia
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Atropisomers are stereoisomers arising because of hindered rotation about a single bond, where energy differences due to steric strain or other contributors create a barrier to rotation that is high enough to allow for isolation of individual conformers.[1][2] They occur naturally and are important in pharmaceutical design.[3] When the substituents are achiral, these conformers are enantiomers (atropoenantiomers), showing axial chirality; otherwise they are diastereomers (atropodiastereomers).[1]