BTB/POZ domain
From Wikipedia, the free encyclopedia
The BTB/POZ domain (BTB for BR-C, ttk and bab[2] or POZ for Pox virus and Zinc finger[3]) is a structural domain found in proteins across the domain Eukarya.[4] Given its prevalence in eukaryotes and its absence in Archaea and bacteria, it likely arose after the origin of eukaryotes.[5] While primarily a protein-protein interaction domain,[5] some BTB domains have additional functionality in transcriptional regulation,[6] cytoskeletal mobility,[7] protein ubiquitination and degradation,[8][9][10] and ion channel formation and operation.[11] BTB domains have traditionally been classified by the other structural features present in the protein.[4]