B recognition element
From Wikipedia, the free encyclopedia
The B recognition element (BRE) is a DNA sequence found in the promoter region of most[clarification needed] genes in eukaryotes and Archaea.[1][2] The BRE is a cis-regulatory element that is found immediately near TATA box, and consists of 7 nucleotides. There are two sets of BREs: one (BREu) found immediately upstream of the TATA box, with the consensus SSRCGCC; the other (BREd) found around 7 nucleotides downstream, with the consensus RTDKKKK.[lower-alpha 1][3][4]
The BREu was discovered in 1998 by Richard Ebright and co-workers.[1] The BREd was named in 2005 by Deng and Roberts;[5] such a downstream recognition was reported earlier in 2000 in Tsai and Sigler's crystal structure.[6]