Basic helix–loop–helix
Protein structural motif / From Wikipedia, the free encyclopedia
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A basic helix–loop–helix (bHLH) is a protein structural motif that characterizes one of the largest families of dimerizing transcription factors.[2][3][4][5] The word "basic" does not refer to complexity but to the chemistry of the motif because transcription factors in general contain basic amino acid residues in order to facilitate DNA binding.[6]
Basic helix–loop–helix DNA-binding domain | |||||||||||
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Identifiers | |||||||||||
Symbol | bHLH | ||||||||||
Pfam | PF00010 | ||||||||||
InterPro | IPR001092 | ||||||||||
SMART | SM00353 | ||||||||||
PROSITE | PDOC00038 | ||||||||||
SCOP2 | 1mdy / SCOPe / SUPFAM | ||||||||||
CDD | cd00083 | ||||||||||
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bHLH transcription factors are often important in development or cell activity. For one, BMAL1-Clock (also called ARNTL) is a core transcription complex in the molecular circadian clock. Other genes, like c-Myc and HIF-1, have been linked to cancer due to their effects on cell growth and metabolism.