Budesonide/formoterol
Medication for asthma & chronic obstructive pulmonary disease / From Wikipedia, the free encyclopedia
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Budesonide/formoterol, sold under the brand name Symbicort among others, is a fixed-dose combination medication used in the management of asthma or chronic obstructive pulmonary disease (COPD).[2] It contains budesonide, a steroid and formoterol, a long-acting β2-agonist (LABA).[2] The product monograph does not support its use for sudden worsening or treatment of active bronchospasm.[2] However, a 2020 review of the literature does support such use.[5] It is used by breathing in the medication.[2]
Combination of | |
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Budesonide | Glucocorticoids |
Formoterol | Long-acting beta-adrenoceptor agonist |
Clinical data | |
Trade names | Symbicort, DuoResp Spiromax, BiResp Spiromax, others |
AHFS/Drugs.com | Professional Drug Facts |
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Routes of administration | Inhalation[2] |
ATC code | |
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KEGG | |
CompTox Dashboard (EPA) | |
Chemical and physical data | |
Formula | C44H58N2O10 |
Molar mass | 774.952 g·mol−1 |
3D model (JSmol) | |
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Common (≥1/100 to <1/10) side effects include candidiasis, headache, tremor, palpitations, throat irritation, coughing, and dysphonia.[6] Pneumonia is a common side effect in people with COPD, and other, less common side effects have been documented.[2][3] There were concerns that the LABA component increases the risk of death in children with asthma, however these concerns were removed in 2017.[7] Therefore, this combination is only recommended in those who are not controlled on an inhaled steroid alone.[2] There is tentative evidence that typical doses of inhaled steroids and LABAs are safe in pregnancy.[8] Both formoterol and budesonide are excreted in breast-milk.[1]
Budesonide/formoterol was approved for medical use in the United States in 2006.[2][9] It is on the World Health Organization's List of Essential Medicines.[10][11] It is available as a generic medication.[12] In 2021, it was the 72nd most commonly prescribed medication in the United States, with more than 9 million prescriptions.[13][14]