CL-218,872
Chemical compound / From Wikipedia, the free encyclopedia
CL-218,872 is a sedative and hypnotic drug used in scientific research.[1][2] It has similar effects to sedative-hypnotic benzodiazepine drugs such as triazolam, but is structurally distinct and so is classed as a nonbenzodiazepine hypnotic.
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ECHA InfoCard | 100.164.099 |
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Formula | C13H9F3N4 |
Molar mass | 278.238 g·mol−1 |
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CL-218,872 is a GABAA partial agonist which is selective for the α1 subtype.[3][4][5] It has a range of effects including sedative, hypnotic, anxiolytic, anticonvulsant and amnestic actions, however the most prominent actions are sedation and amnesia, and CL-218,872 produces effects very similar to those of the hypnotic imidazopyridine derivative zolpidem in animal studies.[6][7][8]
- Moreau S, Coudert P, Rubat C, Gardette D, Vallee-Goyet D, Couquelet J, Bastide P, Tronche P (July 1994). "Synthesis and anticonvulsant properties of new benzylpyridazine derivatives". Journal of Medicinal Chemistry. 37 (14): 2153–60. doi:10.1021/jm00040a006. PMID 8035421.
- Karolak-Wojciechowska J, Lange J, Kwiatkowski W, Gniewosz M, Plenkiewicz J (August 1994). "Bicyclic [b]-heteroannulated pyridazine derivatives--II. Structure-activity relationships in the 6-aryltriazolo-[4,3-b]pyridazine ligands of the benzodiazepine receptor". Bioorganic & Medicinal Chemistry. 2 (8): 773–9. doi:10.1016/s0968-0896(00)82176-8. PMID 7894970.
- Hadingham KL, Wafford KA, Thompson SA, Palmer KJ, Whiting PJ (November 1995). "Expression and pharmacology of human GABAA receptors containing gamma 3 subunits". European Journal of Pharmacology. 291 (3): 301–9. doi:10.1016/0922-4106(95)90070-5. PMID 8719414.
- Araujo F, Tan S, Ruano D, Schoemaker H, Benavides J, Vitorica J (November 1996). "Molecular and pharmacological characterization of native cortical gamma-aminobutyric acidA receptors containing both alpha1 and alpha3 subunits". Journal of Biological Chemistry. 271 (44): 27902–11. doi:10.1074/jbc.271.44.27902. PMID 8910390.
- Atack JR, Smith AJ, Emms F, McKernan RM (March 1999). "Regional differences in the inhibition of mouse in vivo [3H]Ro 15-1788 binding reflect selectivity for alpha 1 versus alpha 2 and alpha 3 subunit-containing GABAA receptors". Neuropsychopharmacology. 20 (3): 255–62. doi:10.1016/S0893-133X(98)00052-9. PMID 10063485.
- Mirza NR, Rodgers RJ, Mathiasen LS (March 2006). "Comparative cue generalization profiles of L-838, 417, SL651498, zolpidem, CL218,872, ocinaplon, bretazenil, zopiclone, and various benzodiazepines in chlordiazepoxide and zolpidem drug discrimination". The Journal of Pharmacology and Experimental Therapeutics. 316 (3): 1291–9. doi:10.1124/jpet.105.094003. PMID 16339395. S2CID 21913400.