Catechol-O-methyltransferase
Class of enzymes / From Wikipedia, the free encyclopedia
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Catechol-O-methyltransferase (COMT; EC 2.1.1.6) is one of several enzymes that degrade catecholamines (neurotransmitters such as dopamine, epinephrine, and norepinephrine), catecholestrogens, and various drugs and substances having a catechol structure.[7] In humans, catechol-O-methyltransferase protein is encoded by the COMT gene.[8] Two isoforms of COMT are produced: the soluble short form (S-COMT) and the membrane bound long form (MB-COMT). As the regulation of catecholamines is impaired in a number of medical conditions, several pharmaceutical drugs target COMT to alter its activity and therefore the availability of catecholamines.[9] COMT was first discovered by the biochemist Julius Axelrod in 1957.[10]
catechol-O-methyltransferase | |||||||||
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Identifiers | |||||||||
EC no. | 2.1.1.6 | ||||||||
CAS no. | 9012-25-3 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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