Catechol 1,2-dioxygenase
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Catechol 1,2- dioxygenase (EC 1.13.11.1, 1,2-CTD, catechol-oxygen 1,2-oxidoreductase, 1,2-pyrocatechase, catechase, catechol 1,2-oxygenase, catechol dioxygenase, pyrocatechase, pyrocatechol 1,2-dioxygenase, CD I, CD II)[1][2][3][4] is an enzyme that catalyzes the oxidative ring cleavage of catechol to form cis,cis-muconic acid:[5]
Catechol 1,2-Dioxygenase | |||||||||
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Identifiers | |||||||||
EC no. | 1.13.11.1 | ||||||||
CAS no. | 9027-16-1 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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More specifically, 1,2-CTD is an intradiol dioxygenase, a family of catechol dioxygenases that cleaves the bond between the phenolic hydroxyl groups of catechol using an Fe3+ cofactor.
Thus far, 1,2-CTD has been observed to exist in the following species of soil bacteria and fungi: Pseudomonas sp.,[6] Pseudomonas fluorescens,[7] Aspergillus niger,[8] Brevibacterium fuscum,[9][10] Acinetobacter calcoaceticus,[11] Trichosporon cutaneum,[12] Rhodococcus erythropolis,[13] Frateuria sp.,[14] Rhizobium trifolii,[15] Pseudomonas putida,[16] Candida tropicalis,[17] Candida maltose,[18] Rhizobium leguminosarum,[19] and Nocardia sp..[20] These bacteria subsequently employ 1,2-CTD in the last step of the degradation of aromatic compounds to aliphatic products.[21]