Central melanocortin system
System involved in the regulation of weight and peripheral tissue such as hair and skin / From Wikipedia, the free encyclopedia
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The central melanocortin system is defined anatomically as a collection of central nervous system circuits which include:
- Neurons that express hypothalamic neuropeptide Y and agouti gene-related protein or proopiomelanocortin and that originate in the arcuate nucleus.
- Brainstem proopiomelanocortic neurons (POMC neurons) originating in the commissural nucleus of the solitary tract (cNTS).
- Downstream targets of these proopiomelanocortic and agouti related protein neurons expressing the melanocortin-3 and melanocortin-4 receptors