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Centromere protein B

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CENPB
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCENPB, entrez:1059, centromere protein B
External IDsOMIM: 117140 MGI: 88376 HomoloGene: 1370 GeneCards: CENPB
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001810

NM_007682

RefSeq (protein)

NP_001801

NP_031708

Location (UCSC)Chr 20: 3.78 – 3.79 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Centromere protein B also known as major centromere autoantigen B is an autoantigen protein of the cell nucleus. In humans, centromere protein B is encoded by the CENPB gene.[4][5][6]

Function

Centromere protein B is a highly conserved protein that facilitates centromere formation. It is a DNA-binding protein that is derived from transposases of the pogo DNA transposon family. It contains a helix-loop-helix DNA binding motif at the N-terminus and a dimerization domain at the C-terminus. The DNA binding domain recognizes and binds a 17-bp sequence (CENP-B box) in the centromeric alpha satellite DNA. This protein is proposed to play an important role in the assembly of specific centromere structures in interphase nuclei and on mitotic chromosomes. It is also considered a major centromere autoantigen recognized by sera from patients with anti-centromere antibodies.

Clinical significance

Centromere protein B is a potential biomarker of small-cell lung cancer.[7]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000125817 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Entrez Gene: centromere protein B".
  5. ^ Sugimoto K, Yata H, Himeno M (July 1993). "Mapping of the human CENP-B gene to chromosome 20 and the CENP-C gene to chromosome 12 by a rapid cycle DNA amplification procedure". Genomics. 17 (1): 240–2. doi:10.1006/geno.1993.1312. PMID 8406460.
  6. ^ Ando S, Yang H, Nozaki N, Okazaki T, Yoda K (April 2002). "CENP-A, -B, and -C chromatin complex that contains the I-type alpha-satellite array constitutes the prekinetochore in HeLa cells". Molecular and Cellular Biology. 22 (7): 2229–41. doi:10.1128/MCB.22.7.2229-2241.2002. PMC 133672. PMID 11884609.
  7. ^ Briasoulis E, Kamposioras K, Tzovaras V, Pafitanis G, Kostoula A, Mavridis A, Pavlidis N (May 2008). "CENP-B specific anti-centromere autoantibodies heralding small-cell lung cancer. A case study and review of the literature". Lung Cancer. 60 (2): 302–6. doi:10.1016/j.lungcan.2007.09.014. PMID 17980453.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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Centromere protein B
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