Chlorphenamine
Antihistamine used to treat allergies / From Wikipedia, the free encyclopedia
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Not to be confused with Chlorphenacemide.
Chlorphenamine (CP, CPM), also known as chlorpheniramine, is an antihistamine used to treat the symptoms of allergic conditions such as allergic rhinitis (hay fever).[2] It is taken orally (by mouth).[2] The medication takes effect within two hours and lasts for about 4–6 hours.[2] It is a first-generation antihistamine and works by blocking the H1 receptor.[2]
Quick Facts Clinical data, Trade names ...
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Trade names | Chlor-Trimeton; Piriton; Chlor-Tripolon |
AHFS/Drugs.com | Monograph |
MedlinePlus | a682543 |
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Routes of administration | Oral, Intravenous, Intramuscular, Subcutaneous |
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Bioavailability | 25 to 50% |
Protein binding | 72% |
Metabolism | Liver (CYP2D6) |
Elimination half-life | 13.9–43.4 hours[1] |
Excretion | Kidney |
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ECHA InfoCard | 100.004.596 |
Chemical and physical data | |
Formula | C16H19ClN2 |
Molar mass | 274.79 g·mol−1 |
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Solubility in water | 0.55 g/100 mL, liquid mg/mL (20 °C) |
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Common side effects include sleepiness, restlessness, and weakness. Other side effects may include dry mouth and wheeziness.[2]
Chlorpheniramine was patented in 1948 and came into medical use in 1949.[3] It is available as a generic medication and over the counter.[2][4]