Clear cell sarcoma
Rare form of cancer / From Wikipedia, the free encyclopedia
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Clear cell sarcoma is a rare form of cancer called a sarcoma.[1] It is known to occur mainly in the soft tissues and dermis. Rare forms were thought to occur in the gastrointestinal tract before they were discovered to be different and redesignated as gastrointestinal neuroectodermal tumors.
Clear cell sarcoma | |
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Other names | Malignant melanoma of the soft parts |
Clear cell sarcoma. Tumor cells with prominent nucleoli and clear cytoplasm are arranged in well-defined nests surrounded by dense fibrous stroma. | |
Specialty | Oncology |
Recurrence is common.[2]
Clear cell sarcoma's neoplastic cells express the EWSR1-ATF1 fusion gene in a majority of cases or a EWSR1-CREB1, EWSR1-CREM,[3] or EWSR1-DDIT3[4] fusion gene in a small subset of cases (see FET gene family of fusion genes).
Clear cell sarcoma of the soft tissues in adults is not related to the pediatric tumor known as clear cell sarcoma of the kidney.[5]