CoRR hypothesis
Biological hypothesis / From Wikipedia, the free encyclopedia
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The CoRR hypothesis states that the location of genetic information in cytoplasmic organelles permits regulation of its expression by the reduction-oxidation ("redox") state of its gene products.
CoRR is short for "co-location for redox regulation", itself a shortened form of "co-location (of gene and gene product) for (evolutionary) continuity of redox regulation of gene expression".[1][2]
CoRR was put forward explicitly in 1993 in a paper in the Journal of Theoretical Biology with the title "Control of gene expression by redox potential and the requirement for chloroplast and mitochondrial genomes".[3] The central concept had been outlined in a review of 1992.[4] The term CoRR was introduced in 2003 in a paper in Philosophical Transactions of the Royal Society entitled "The function of genomes in bioenergetic organelles".[5]