Collagen, type VII, alpha 1
Protein found in humans / From Wikipedia, the free encyclopedia
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Collagen alpha-1(VII) chain is a protein that in humans is encoded by the COL7A1 gene.[5] It is composed of a triple helical, collagenous domain flanked by two non-collagenous domains, and functions as an anchoring fibril between the dermal-epidermal junction in the basement membrane.[6] Mutations in COL7A1 cause all types of dystrophic epidermolysis bullosa, and the exact mutations vary based on the specific type or subtype.[7] It has been shown that interactions between the NC-1 domain of collagen VII and several other proteins, including laminin-5 and collagen IV, contribute greatly to the overall stability of the basement membrane.[6][8]