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Combination drug for HIV From Wikipedia, the free encyclopedia
Emtricitabine/rilpivirine/tenofovir, sold under the brand name Complera among others, is a fixed-dose combination of antiretroviral drugs for the treatment of HIV/AIDS.[4] The drug was co-developed by Gilead Sciences and Johnson & Johnson's Tibotec division and was approved by the US Food and Drug Administration (FDA) in August 2011, and by the European Medicines Agency in November 2011,[3][5] for patients who have not previously been treated for HIV.[6] It is available as a once-a-day single tablet.
Combination of | |
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Emtricitabine | Nucleoside analog reverse-transcriptase inhibitor |
Rilpivirine | Non-nucleoside reverse transcriptase inhibitor |
Tenofovir disoproxil | Nucleotide analog reverse-transcriptase inhibitor |
Clinical data | |
Trade names | Complera, Eviplera |
AHFS/Drugs.com | Multum Consumer Information |
MedlinePlus | a616021 |
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Routes of administration | By mouth |
ATC code | |
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In the European Union it is marketed as Eviplera and in the US as Complera.[7]
Emtricitabine/rilpivirine/tenofovir is indicated for treatment of HIV-1 in adults naïve to HIV-1 medications (where the virus has not developed resistance to these anti-HIV medications) and who have no more than 100,000 copies per mL of HIV-1 RNA in their blood (“viral load”).[8][9]
Contraindications
Use of emtricitabine/rilpivirine/tenofovir with the following medicines is contraindicated, as they lead to reduced blood levels of rilpivirine and in turn reduce the effectiveness of emtricitabine/rilpivirine/tenofovir:[8][11]
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