Desmoglein-2
Protein found in humans / From Wikipedia, the free encyclopedia
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Desmoglein-2 is a protein that in humans is encoded by the DSG2 gene.[5][6] Desmoglein-2 is highly expressed in epithelial cells and cardiomyocytes. Desmoglein-2 is localized to desmosome structures at regions of cell-cell contact and functions to structurally adhere adjacent cells together. In cardiac muscle, these regions are specialized regions known as intercalated discs. Mutations in desmoglein-2 have been associated with arrhythmogenic right ventricular cardiomyopathy and familial dilated cardiomyopathy.[7]
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