Dermcidin

Dermcidin is a protein with 110 amino acids that in humans is encoded by the DCD gene.[3][4] The full-length protein produces derived peptides as proteolysis-inducing factor (PIF) and other anti-microbial peptides,[4] secreted by human eccrine sweat glands onto the skin as a part of the innate host defense of the immune system. PIF is involved in muscular proteolysis.[4]

Quick facts: DCD, Available structures, PDB, List of PDB i... ▼

DCD
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2YMK, 2KSG
Identifiers
Aliases	DCD, AIDD, DCD-1, DSEP, HCAP, PIF, dermcidin
External IDs	OMIM: 606634 HomoloGene: 89039 GeneCards: DCD
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q13.2 Start 54,644,589 bp[1] End 54,648,493 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of abdomen gastrocnemius muscle nipple sural nerve subcutaneous adipose tissue popliteal artery right lung left ventricle right lobe of liver ascending aorta n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase activity protein binding hydrolase activity RNA binding Cellular component extracellular exosome extracellular matrix extracellular region extracellular space Biological process defense response to bacterium proteolysis antimicrobial humoral response antimicrobial humoral immune response mediated by antimicrobial peptide killing of cells of other organism defense response to fungus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 117159 n/a Ensembl ENSG00000161634 n/a UniProt P81605 n/a RefSeq (mRNA) NM_053283 NM_001300854 n/a RefSeq (protein) NP_001287783 NP_444513 n/a Location (UCSC) Chr 12: 54.64 – 54.65 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human