Dienestrol
Chemical compound / From Wikipedia, the free encyclopedia
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Dienestrol (INNTooltip International Nonproprietary Name, USANTooltip United States Adopted Name) (brand names Dienoestrol, Denestrolin, Dienol and many others[lower-alpha 1]), also known as dienoestrol (BANTooltip British Approved Name), is a synthetic nonsteroidal estrogen medication of the stilbestrol group which is or was used to treat menopausal symptoms in the United States and Europe.[1][2][3][4] It has been studied for use by rectal administration in the treatment of prostate cancer in men as well.[5] The medication was introduced in the U.S. in 1947 by Schering as Synestrol and in France in 1948 as Cycladiene.[4] Dienestrol is a close analogue of diethylstilbestrol.[6] It has approximately 223% and 404% of the affinity of estradiol at the ERα and ERβ, respectively.[7]
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Trade names | Ortho Dienestrol, Dienoestrol, Dienoestrol Ortho, Sexadien, Cycladiene, Denestrolin, Dienol, Dinovex, Follormon, Oestrodiene, Synestrol |
Other names | Dienoestrol; p-[(E,E)-1-Ethylidene-2-(p-hydroxyphenyl)-2-butenyl]phenol; 3,4-Di(para-hydroxyphenyl)-2,4-hexadiene |
AHFS/Drugs.com | Micromedex Detailed Consumer Information |
Drug class | Nonsteroidal estrogen |
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ECHA InfoCard | 100.001.381 |
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Formula | C18H18O2 |
Molar mass | 266.340 g·mol−1 |
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Dienestrol diacetate (brand names Faragynol, Gynocyrol, others) also exists and has been used medically.[2]