Dimetacrine
Chemical compound / From Wikipedia, the free encyclopedia
Dimetacrine (brand names Istonil, Istonyl, Linostil, Miroistonil), also known as dimethacrine and acripramine, is a tricyclic antidepressant (TCA) used in Europe and formerly in Japan for the treatment of depression.[2][3][4][5][6] It has imipramine-like effects; though, in a double-blind clinical trial against imipramine, dimetacrine was found to have lower efficacy in comparison and produced more weight loss and abnormal liver tests.[7][8]
Quick Facts Clinical data, Trade names ...
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Trade names | Istonil, Istonyl, Linostil, Miroistonil |
Routes of administration | Oral |
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Formula | C20H26N2 |
Molar mass | 294.442 g·mol−1 |
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Little is known about the pharmacology of dimetacrine,[9] but it can be inferred that it acts in a similar manner to other TCAs. If this is indeed the case, dimetacrine may induce severe cardiac toxicity in overdose (a side effect unique to the tricyclic class of antidepressants).