Dolichyl-phosphate alpha-N-acetylglucosaminyltransferase

In enzymology, a dolichyl-phosphate alpha-N-acetylglucosaminyltransferase (EC 2.4.1.153) is an enzyme that catalyzes the chemical reaction

UDP-N-acetyl-D-glucosamine + dolichyl phosphate ${\displaystyle \rightleftharpoons }$ UDP + dolichyl N-acetyl-alpha-D-glucosaminyl phosphate

dolichyl-phosphate alpha-N-acetylglucosaminyltransferase
Identifiers
EC no.	2.4.1.153
CAS no.	63363-73-5
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

Thus, the two substrates of this enzyme are UDP-N-acetyl-D-glucosamine and dolichyl phosphate, whereas its two products are UDP and dolichyl N-acetyl-alpha-D-glucosaminyl phosphate.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-N-acetyl-D-glucosamine:dolichyl-phosphate alpha-N-acetyl-D-glucosaminyltransferase. Other names in common use include uridine diphosphoacetylglucosamine-dolichol phosphate, acetylglucosaminyltransferase, dolichyl phosphate acetylglucosaminyltransferase, dolichyl phosphate N-acetylglucosaminyltransferase, UDP-N-acetylglucosamine-dolichol phosphate, and N-acetylglucosaminyltransferase.

References

• Leloir LF, Staneloni RJ, Carminatti H, Behrens NH (1973). "The biosynthesis of a N,N'-diacetylchitobiose containing lipid by liver microsomes. A probable dolichol pyrophosphate derivative". Biochem. Biophys. Res. Commun. 52 (4): 1285–92. doi:10.1016/0006-291X(73)90640-2. hdl:11336/141022. PMID 4717748.
• Molnar J, Chao H, Ikehara Y (1971). "Phosphoryl-N-acetylglucosamine transfer to a lipid acceptor of liver microsomal preparations". Biochim. Biophys. Acta. 239 (3): 401–10. doi:10.1016/0005-2760(71)90033-6. PMID 5113503.
• Tetas M, Chao H, Molnar J (1970). "Incorporation of carbohydrates into endogenous acceptors of liver microsomal fractions". Arch. Biochem. Biophys. 138 (1): 135–46. doi:10.1016/0003-9861(70)90292-4. PMID 4315690.
• Warren CD, Jeanloz RW (1974). "Chemical synthesis of P1-2-acetamido-2-deoxy-alpha-D-glucopyranosyl P2-dolichyl pyrophosphate". Carbohydr. Res. 37 (1): 252–60. doi:10.1016/S0008-6215(00)87080-9. PMID 4371972.