Uronate dehydrogenase

In enzymology, an uronate dehydrogenase (EC 1.1.1.203) is an enzyme that catalyzes the chemical reaction

D-galacturonate + NAD⁺ + H₂O ${\displaystyle \rightleftharpoons }$ D-galactaro-1,5-lactone + NADH + H⁺

uronate dehydrogenase
Identifiers
EC no.	1.1.1.203
CAS no.	37250-98-9
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

The 3 substrates of this enzyme are D-galacturonate, NAD⁺, and H₂O, whereas its 3 products are D-galactaro-1,5-lactone (the lactone of D-galactarate), NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is uronate:NAD⁺ 1-oxidoreductase. Other names in common use include uronate: NAD-oxidoreductase, and uronic acid dehydrogenase.