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Enzyme From Wikipedia, the free encyclopedia
In enzymology, a mRNA (nucleoside-2'-O-)-methyltransferase (EC 2.1.1.57) is an enzyme that catalyzes the chemical reaction
mRNA (nucleoside-2'-O-)-methyltransferase | |||||||||
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Identifiers | |||||||||
EC no. | 2.1.1.57 | ||||||||
CAS no. | 61970-02-3 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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Thus, the two substrates of this enzyme are S-adenosyl methionine and m7G(5')pppR-RNA, whereas its two products are S-adenosylhomocysteine and m7G(5')pppRm-RNA (mRNA containing a 2'-O-methylpurine cap).
This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:mRNA (nucleoside-2'-O-)-methyltransferase. Other names in common use include messenger ribonucleate nucleoside 2'-methyltransferase, and messenger RNA (nucleoside-2'-)-methyltransferase.
As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 2GA9 and 2GAF.
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