ATP citrate synthase
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ATP citrate synthase (also ATP citrate lyase (ACLY)) is an enzyme that in animals represents an important step in fatty acid biosynthesis.[2] By converting citrate to acetyl-CoA, the enzyme links carbohydrate metabolism, which yields citrate as an intermediate, with fatty acid biosynthesis, which consumes acetyl-CoA.[3] In plants, ATP citrate lyase generates cytosolic acetyl-CoA precursors of thousands of specialized metabolites, including waxes, sterols, and polyketides.[4]
Quick Facts Identifiers, EC no. ...
ATP citrate synthase | |||||||||
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Identifiers | |||||||||
EC no. | 2.3.3.8 | ||||||||
CAS no. | 9027-95-6 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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Quick Facts Human ATP citrate lyase, Identifiers ...
Human ATP citrate lyase | |||||||
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Identifiers | |||||||
Symbol | ACLY | ||||||
Alt. symbols | ACL | ||||||
NCBI gene | 47 | ||||||
HGNC | 115 | ||||||
OMIM | 108728 | ||||||
PDB | 3MWE, 3PFF, 5TDE, 5TDF, 5TDM, 5TDZ, 5TE1, 5TEQ, 5TES, 5TET, 6HXH, 6HXK, 6HXL, 6HXM, 6O0H, 6QFB 3MWD, 3MWE, 3PFF, 5TDE, 5TDF, 5TDM, 5TDZ, 5TE1, 5TEQ, 5TES, 5TET, 6HXH, 6HXK, 6HXL, 6HXM, 6O0H, 6QFB | ||||||
RefSeq | NM_001096 | ||||||
UniProt | P53396 | ||||||
Other data | |||||||
EC number | 2.3.3.8 | ||||||
Locus | Chr. 17 q21.2 | ||||||
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